The THAP1 Antibody BIOTIN from MyBioSource.com is a Rabbit Polyclonal antibody. This antibody recognizes Human antigen. The THAP1 Antibody BIOTIN has been validated for the following applications: ELISA, Immunocytochemistry, Immunoprecipitation, and Western Blot.
Description
Overview: DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptopic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Structure: Belongs to the THAP1 family.
Expression: Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta